Researchers have found in a new study that The TyG index is an independent risk factor for the degree of coronary stenosis and a better predictor in patients with H-type hypertension combined with coronary artery disease.
The study conducted at Wuhan Third Hospital delves into the prognostic significance of the Triglyceride-Glucose (TyG) index in individuals diagnosed with H-type hypertension and coronary artery disease. The findings shed light on the association between TyG levels and the severity of coronary artery stenosis, emphasizing its potential as a robust predictive tool for cardiovascular risk.

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, with China experiencing its devastating effects as the primary cause of death and premature mortality
This study was published in the journal BMC Cardiovascular Diabetology by Zhengwen Xu and colleagues. The cohort comprised 320 inpatients diagnosed with hypertension and coronary artery disease. The key findings of the study were:
Correlation with Stenosis Severity:
• Positive correlation observed between elevated TyG levels and increased susceptibility to severe stenosis in H-type hypertension patients.
• Odds Ratio (OR) for severe stenosis: 4000 (95% CI 2.411-6.635, p = 0.0001).
• OR for multivessel disease: 1.862 (95% CI 1.036-3.348, p < 0.0001).
Predictive Ability of TyG Index:
• TyG index demonstrated superior predictive ability for severe coronary stenosis in H-type hypertension patients:
• Area Under the Curve (AUC): 0.888 (95% CI 0.838-0.939, p < 0.0001).
• Compared to AUC in patients without H-type hypertension: 0.615 (95% CI 0.494-0.737, p < 0.05).
The study concludes that the TyG index is an independent risk factor for the degree of coronary stenosis, particularly in patients with H-type hypertension combined with coronary artery disease. The robust association between elevated TyG levels and severe stenosis underscores its potential as a valuable tool for cardiovascular risk assessment in this specific patient population.
Reference:
Xu, Z., Chen, P., Wang, L., Yan, J., Yan, X., & Li, D. Relationship between TyG index and the degree of coronary artery lesions in patients with H-type hypertension. Cardiovascular Diabetology,2024;23(1). https://doi.org/10.1186/s12933-023-02013-0