UK: A brain-computer interface (BCI) surgically implanted in a 45-year-old man with amyotrophic lateral sclerosis (ALS) and severe dysarthria worked well enough to swiftly restore conversational speech, according to research published in the New England Journal of Medicine on August 14, 2024.
Amyotrophic lateral sclerosis (ALS), sometimes known as ALS, is a neurological illness that destroys nerve cells in the brain and spinal cord. ALS leads to loss of muscular control. Muscle twitching and weakness in an arm or leg, as well as difficulty swallowing or slurred speech, are common early signs of ALS. ALS eventually impairs control of the muscles required to move, speak, eat, and breathe. There is no cure for this deadly condition. Nicholas S. Card, From the Departments of Neurological Surgery, Boston, et.al report the result of decoding the neural cortical activity of a 45-year-old man.

For the conduction of the research, a 45-year-old man with amyotrophic lateral sclerosis, tetraparesis, and severe dysarthria, had four microelectrode arrays surgically implanted into his left ventral precentral gyrus 5 years after the disease began; these arrays recorded neural activity from 256 intracortical electrodes.
The Decoded phrases were shown on a screen before being vocalized using text-to-speech software that mimicked his pre-ALS voice.
They revealed that on the first day of use (25 days after surgery), the neuroprosthesis obtained 99.6% accuracy with a 50-word vocabulary. Calibration of the neuroprosthesis involved 30 minutes of brain recordings while the person spoke, followed by processing. After 1.4 hours of system training on the second day, the neuroprosthesis achieved 90.2% accuracy with a vocabulary of 125,000 words. The neuroprosthesis maintained 97.5% accuracy after 8.4 months of usage, allowing for self-paced discussions at a rate of 32 words per minute for over 248 hours.
“After brief training, an intracortical speech neuroprosthesis performed well enough to restore conversational communication in a person with ALS and severe dysarthria”, researchers concluded.
Reference
Elizabeth G. Phimister, Edward F. Chang, Brain-Computer Interfaces for Restoring Communication, New England Journal of Medicine, 391, 7, (654-657), (2024)./doi/full/10.1056/NEJMe2407363