Study on the Risks of Combining DOAC and Aspirin

Researchers have found in an observational study that concomitant use of a direct oral anticoagulant (DOAC) plus aspirin in some cardiovascular patients without a clear indication for aspirin is associated with increased bleeding risks.

The new study published in JAMA Internal Medicine confirms that more blood thinners aren't automatically better. The study focuses on the minimal pros and the concerning cons of combining a daily aspirin with a drug from the newer class of anticoagulants that include apixaban, dabigatran, edoxaban, and rivaroxaban.

Aspirin (ASA) is a nonselective COX inhibitor and is generally prescribed to prevent and manage coronary artery disease, peripheral vascular disease, and stroke. Aspirin, however, is not currently indicated for nonvalvular atrial fibrillation or venous thromboembolism (VTE), whose mainstay of treatment primarily consists of direct oral anticoagulation (DOAC).

Patients were taking one of these direct oral anticoagulants known as DOACs to prevent strokes from non-valvular atrial fibrillation or for the treatment of venous thromboembolic disease (deep vein thrombosis or pulmonary embolism). The included patients did not have another reason to take aspirin such as a recent history of a heart attack or a history of a heart valve replacement. The researchers discovered that almost one-third of the people who were prescribed a DOAC were also taking aspirin without a clear reason for the aspirin.

"The patients on combination therapy were more likely to have bleeding events but they weren't less likely to have a blood clot," says lead author Jordan Schaefer, M.D., an assistant professor of internal medicine and a hematologist at Michigan Medicine, the academic medical center of the University of Michigan. "Therefore, it's important that patients ask their doctors if they should be taking aspirin when they are prescribed a direct oral anticoagulant."

The combination of an anticoagulant and an antiplatelet may be appropriate for people who have had a recent heart attack, recent coronary stent placement or bypass surgery, prior mechanical valve surgery or known peripheral artery disease, among other conditions says co-author Geoffrey Barnes, M.D., M.Sc., an assistant professor of internal medicine and a vascular cardiologist at the Michigan Medicine Frankel Cardiovascular Center.

For the others, "combination therapy may not be happening intentionally; rather, the addition of aspirin might get overlooked because it's not in any one specialist or general care provider's territory," Barnes says.

The authors note that there are many medical conditions and situations where adding aspirin with a direct oral anticoagulant has not been adequately studied. Schaefer adds that they plan to confirm their study findings in a larger, longer study because there were not many blood clots that occurred during the timeframe of this study, potentially limiting their ability to assess if aspirin could be beneficial.

Previously, Schaefer and Barnes also reported a significant increase in adverse outcomes for people taking both aspirin and warfarin, a different kind of anticoagulant.

For further reference log on to: http://dx.doi.org/10.1001/jamainternmed.2021.1197