Bleeding and wound infection are the most common complications of circumcision. Cyanoacrylate tissue glue has been claimed to have the advantage of being haemostatic, bacteriostatic and easy to use.Tissue glue has been examined extensively for its effectiveness in pediatrics, and the findings are good.
The use of tissue glue is tied with a reduction in pain during Pediatric Circumcision Wound Approximation, according to a meta-analysis of randomized controlled trial.
The findings of the study have been published in the Journal of Pediatric Urology
The purpose of this research was to examine the effectiveness of tissue glue compared to absorbable sutures for wound approximation in pediatric circumcision.
A systematic review and meta-analysis of the English literature (1997-2021) on children who had circumcision using tissue glue and absorbable suture were done in line with the PRISMA criteria. RevMan 5.4 was used to perform the meta-analysis. The mean differences for continuous and dichotomous data are determined using inverse variance, and the odds ratio is calculated using the Mantel-Haenszel technique.
The results of the study are:
The inclusion criteria were met by six trials containing a total of 817 patients. According to the analysis, tissue glue significantly reduces the duration of the operation (MD – 7.98; 95% CI -12.35, -3.62; p = 0.0003), pain severity (SMD -0.56; 95%CI -0.80, -0.66; p <0.00001) and the duration of pain (MD - 0.56; 95% CI -2.57, -2.08; p <0.00001) compared to absorbable suture. However, we found that there was no significant difference in the incidence of postoperative bleeding, infection, dehiscence, or overall complication when comparing absorbable sutures to traditional sutures.
Thus, the researchers concluded that their systematic review and meta-analysis using the most recent data suggest that tissue glue usage might reduce the operation time, as well as the intensity and duration of postoperative pain.
Reference:
The Efficacy of Tissue Glue in Pediatric Circumcision Wound Approximation: A Meta-analysis of Randomized Controlled Trial by Yufi Aulia Azmi et al. published in the Journal of Pediatric Urology
https://www.jpurol.com/article/S1477-5131(22)00105-X/fulltext