Lotilaner Ophthalmic Solution Study

Lotilaner ophthalmic solution may improve clinical signs of Demodex blepharitis for up to one year, suggests a study published in the Cornea.

This study aimed to evaluate the long-term outcomes of lotilaner ophthalmic solution, 0.25%, in the treatment of Demodex blepharitis. This observational, extension study included patients with Demodex blepharitis (N = 239) who completed the Saturn-1 study and presented for the day 180 visit. All participants were assessed at days 180 and 365 after the initiation of 6-week treatment with the study drug or its vehicle.

Results

• The proportion of patients with 0 to 2 collarettes (grade 0) was significantly higher in the study group (N = 128 patients) than in the control group (N = 111 patients) (39.8% vs. 2.7% at day 180 and 23.5% vs. 2.9% at day 365; P < 0.0001).
• Similarly, the proportion of patients with ≤10 collarettes (collarette grade 0–1) in the study group was significantly higher than in the control group (70.3% vs. 18.0% at day 180 and 62.6% vs. 21.9% at day 365; P < 0.0001).
• In the study group, erythema continued to improve even after completion of the 6-week lotilaner treatment.
• No serious ocular adverse events were observed in the study group, and there was 1 treatment-related ocular adverse event in the study group, which was considered mild.

After 6-week treatment with lotilaner ophthalmic solution, 0.25%, for Demodex blepharitis, no long-term concerns were observed during 1 year of follow-up. A high proportion of patients with 0 to 2 collarettes (grade 0) or ≤10 collarettes (collarette grade of 0 or 1) was observed throughout 1 year of follow-up, indicating that the efficacy of lotilaner ophthalmic solution, 0.25%, against Demodex blepharitis may last well after completion of therapy.

Reference

Sadri, Ehsan MD*; Paauw, James D. MD†; Ciolino, Joseph B. MD‡; Nijm, Lisa MD, JD§; Simmons, Blake OD¶; Meyer, John MD║; Gaddie, Ian Benjamin OD**; Berdy, Gregg J. MD††; Holdbrook, Mark BA‡‡; Baba, Stephanie N. OD‡‡; Jalalat, Parisa OD*; Yeu, Elizabeth MD§§. Long-Term Outcomes of 6-Week Treatment of Lotilaner Ophthalmic Solution, 0.25%, for Demodex Blepharitis: A Noninterventional Extension Study. Cornea ():10.1097/ICO.0000000000003484, February 9, 2024. | DOI: 10.1097/ICO.0000000000003484.