A recent study by Roger Henriksen and team found that depression or sleeplessness are mediating the effect of loneliness on type 2 diabetes. Loneliness may be one component that raises the chance of developing the disease. The findings of this study were published in Diabetologia Journal.

PAUSE
The incidence of type 2 diabetes, one of the main causes of mortality worldwide, has drastically climbed during the past 20 years. Loneliness may be a type 2 diabetes risk factor, according to recent research. This 20-year follow-up research looked at the possibility that loneliness raises the incidence of type 2 diabetes. Researchers also looked at whether any correlation between loneliness and type 2 diabetes is mediated by signs of sadness and sleeplessness as both type 2 diabetes and loneliness have been associated with depression and sleep issues.

The Trndelag Health Study (HUNT study), a significant longitudinal health study with a population from central Norway (n=24,024), provided the data. To assess the relationships between loneliness and type 2 diabetes incidence, self-reports of loneliness from the HUNT2 survey, conducted between 1995 and 1997, and data on HbA1c levels from the HUNT4 survey, conducted between 2017 and 2019, were both analyzed. For sex, age, and education adjustments, associations were expressed as ORs with 95% CIs. The significance of depression and sleeplessness as potential mediating variables was further explored in this study.
The key findings of this study were:

1.4.9% of those who took part in the trial went on to acquire type 2 diabetes throughout the 20-year follow-up period.
2.12.6% of the individuals reported feeling lonely to varying degrees.
3.Comparing those who felt the most lonely to those who did not, type 2 diabetes risk was increased by threefold (adjusted OR 2.19; 95% CI 1.16, 4.15).
4.One subtype of sleeplessness, but not depressive symptoms, was a marginally effective mediator of the effect of loneliness on type 2 diabetes.
Reference:
Henriksen, R. E., Nilsen, R. M., & Strandberg, R. B. (2022). Loneliness increases the risk of type 2 diabetes: a 20 year follow-up – results from the HUNT study. In Diabetologia (Vol. 66, Issue 1, pp. 82–92). Springer Science and Business Media LLC. https://doi.org/10.1007/s00125-022-05791-6