PRISM Mapping in Persistent Atrial Fibrillation

Persistent atrial fibrillation (AF), a challenging condition to manage, has often shown limited response to catheter ablation. A novel approach known as periodicity and similarity (PRISM) mapping has demonstrated remarkable success in a prospective randomized clinical trial for Persistent AF treatment, conducted across three centers in Asia. The outcomes were published in the Journal of American Medical Association.

Clinical Trial Overview

In this trial conducted between June 2019 and December 2020, patients were assigned to either the PRISM-guided approach (group 1) or the conventional approach (group 2) at a 1:1 ratio. The primary outcome measured was freedom from AF or other atrial arrhythmias lasting longer than 30 seconds at 6 and 12 months.

Results

The results found that patients in the PRISM-guided group exhibited a significantly higher rate of freedom from AF at the 12-month mark compared to those in the conventional group (70.6% vs. 47.1%). Multivariate analysis further underscored the efficacy of the PRISM-guided approach, revealing a hazard ratio of 0.53 (95% CI, 0.33-0.85), signifying a substantial reduction in the recurrence of atrial arrhythmias.

PRISM Mapping Technique

The PRISM mapping technique, which analyzes waveform similarity and recurrence patterns through high-density mapping, offers a promising advancement in guiding the ablation process for persistent AF. This specific substrate ablation strategy not only reduced the frequency of recurrent AF but also increased the likelihood of maintaining sinus rhythm.

Significance

This study is important in the field of AF treatment, providing hope for improved outcomes and potentially paving the way for a more effective and targeted approach to catheter ablation. As the medical community eagerly awaits further validation and adoption of this innovative strategy, the PRISM mapping approach emerges as a beacon of progress in the evolving landscape of cardiac arrhythmia management.

Reference

Lin, C.-Y., Lin, Y.-J., Higa, S., Tsai, W.-C., Lo, M.-T., Chiang, C.-H., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Chao, T.-F., Chung, F.-P., Liao, J.-N., Chang, T.-Y., Lin, C., Tuan, T.-C., Kuo, L., Wu, C.-I., Liu, C.-M., Liu, S.-H., … Chen, S.-A. (2023). Catheter ablation with morphologic repetitiveness mapping for persistent atrial fibrillation. JAMA Network Open, 6(11), e2344535. https://doi.org/10.1001/jamanetworkopen.2023.44535