Full-field electroretinography may help evaluate retinal function in patients with retinal vasculitis suggests a recent study published in the British Journal of Ophthalmology
A study was conducted to describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).
Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.
Results:20 patients (34 eyes) were included.
• The mean age was 43.9±19.8 years; 70% were female.
• The median best-corrected visual acuity was 0.8 (0.08–1).
• The mean FFA score was 12.6±6.5.
• The median general ffERG score was 5 (0–6). 68% and 91% of eyes had responses with available ffERG scores ≥5 and 4, respectively.
• Flicker timing was most commonly affected.
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FFA scores were weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively).
• Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03).
• The underlying systemic disease was associated with poor ffERG responses.
In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.
Reference:
Ghoraba HH, Matsumiya W, Or C, et al. Electroretinographic findings in retinal vasculitisBritish Journal of Ophthalmology Published Online First: 21 September 2022. doi: 10.1136/bjo-2022-321716.
Keywords:
British Journal of Ophthalmology, Ghoraba HH, Matsumiya W, Or C, Electroretinographic findings, retinal vasculitis, Full-field, electroretinography, evaluate, retinal, function, patients, retinal vasculitis