Endosalpingiosis: An Ectopic Endothelial Abnormality

Endosalpingiosis is an ectopic endothelial abnormality. It is a poorly understood condition of ectopic epithelium resembling the fallopian tubes. It has been described as an incidental pathology finding, a disease similar to endometriosis, and in association with malignancy.

According to a retrospective case-control study, endosalpingiosis doubled the risk of concurrent gynecologic malignancy as compared with endometriosis and conferred worse overall survival (OS).

Study Publication

The study has been published in the Gynecologic Oncology.

Endosalpingiosis is a poorly understood condition of ectopic epithelium resembling the fallopian tubes. It has been described as an incidental pathology finding, a disease similar to endometriosis, and in association with malignancy. The objective of this study is to determine if endosalpingiosis (ES) has an increased association with gynecologic malignancy when compared to endometriosis (EM).

This is a retrospective case-control analysis of patients with a histologic diagnosis of endosalpingiosis or endometriosis at three affiliated academic hospitals between 2000 and 2020. All endosalpingiosis patients were included, and 1:1 matching was attempted to obtain a comparable cohort of endometriosis patients. Demographic and clinical data were obtained, and statistical analysis was performed.

Study Results

• A total of 967 patients (515 ES and 452 EM) were included.
• Endosalpingiosis patients were significantly older than endometriosis patients.
• The endosalpingiosis group had significantly more cancer diagnoses at surgery than the endometriosis group; this difference persisted in a sub-analysis excluding patients with known or suspected malignancy.
• Endosalpingiosis patients had lower overall survival.
• After adjusting for confounders, multivariable analysis showed that endosalpingiosis patients had increased cancer diagnosed at surgery and greater risk of death.
• Endosalpingiosis was found concurrently with malignancy in 40% of cases, and this effect was preserved in multi-variable and sub-group analyses.

Further research consisting of longer follow-up and exploration of molecular relationships between endosalpingiosis and cancer are forthcoming.

Reference

Gregory K. Lewis et al. The association of endosalpingiosis with gynecologic malignancy. Published: July 28, 2022. DOI: https://doi.org/10.1016/j.ygyno.2022.07.025