A new study published inScientific Reportshas found that higher dietary choline consumption is linked to greater bone mineral density (BMD) in postmenopausal women, a group highly vulnerable to osteoporosis. Since the accelerated bone loss caused by estrogen deficiency during menopause, identification of modifiable dietary factors such as choline is important for establishing osteoporosis prevention strategies. The study was conducted by Jincheng and colleagues. The study involved 4,160 postmenopausal women aged 50 years and above with no exclusion based on income or ethnicity. The information was captured in six cycles of the NHANES from 2007 through 2018. Researchers used weighted linear regression models to test how cumulative dietary choline consumption was associated with lumbar spine bone mineral density. The models were completely adjusted for suspected confounders, such as age, race, income level, body mass index (BMI), and comorbidities. Stratified analyses were performed to determine whether socioeconomic and demographic characteristics altered the detected effects. Key Findings With every 1 g/day higher choline intake, there was a 0.082 g/cm² rise in lumbar spine BMD (β: 0.082, 95% CI: 0.025–0.139). Participants in the highest quartile of choline consumption (Q4) also had a 0.025 g/cm² greater BMD than those in the lowest quartile (Q1) (β: 0.025, 95% CI: 0.007–0.042). The association was significantly larger in some subgroups: Obese women had a greater effect size of 0.146 g/cm² (95% CI: 0.067–0.220, P interaction = 0.015). High-income women (PIR > 4) experienced a rise in BMD of 0.121 g/cm² (95% CI: 0.013–0.228, P interaction = 0.003). Non-Hispanic White women had a BMD increase of 0.110 g/cm² (95% CI: 0.034–0.185, P interaction = 0.039). This research yields the first holistic evidence that increased dietary choline is positively associated with higher lumbar spine BMD in postmenopausal women, especially in obese women, high-income populations, and non-Hispanic Whites. These results indicate the promise of choline-focused nutritional interventions for the prevention of osteoporosis in this at-risk population. The role of income and race also highlights the importance of equitable diet interventions able to reach the bone health disparity among aging women. Bai, J., Lv, P., Li, L. et al. Association between total dietary choline intake and lumbar spine bone mineral density in postmenopausal women based on NHANES 2007–2018. Sci Rep 15, 23483 (2025).https://doi.org/10.1038/s41598-025-08891-6