Turkey: According to a recent surgery published in "The Surgeon", a team of researchers in their study have mentioned that a relationship exists between obesity and NLRP3 inflammasome. Considering the inflammatory parameters, which are higher in the preoperative period or before weight loss surgery, a study has found a decrease in inflammatory parameters after Roux-en-Y gastric bypass.
It is already known that obesity causes chronic inflammation. Evaluating further and finding changes in Nesfatin-1 and serum cytokine levels following sleeve gastrectomy or gastric bypass surgery, researchers did a study on 30 patients having BMI greater than 35.
There were two groups, the sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB).
The values noted from hospitalisation till follow-up was related to demographics, weight, BMI, AST, ALT, blood glucose, CRP values, inflammatory markers and Nesfatin-1.
The study points include the following:
The study included 16 females and 14 males with a mean age of 37.56 ± 11.73 years.
The RYGB group had higher body weight and excess weight change than the SG group.
Compared to the preoperative period, there was a significant reduction in glucose, AST, ALT, CRP, IL-6, IL-10, and IL-18 values in RYGB and SG patients.
There was a slight increase in serum Nesfatin-1 levels in RYGB patients, not SG patients.
RYGB patients had significant decreases in IL-1β levels.
Both methods reduced cytokines except IL-17A, but it was insignificant.
Concluding further, the researchers said, “The present study shows that there occurs regression in inflammation, which can be associated with NLRP3 inflammasome, due to weight loss after bariatric surgery. This is more specifically related to RYGB.”
Further reading:
Effect of bariatric surgery procedures on serum cytokine and Nesfatin-1 levels.https://doi.org/10.1016/j.surge.2023.03.002